Dr Renaud Caous
I carried out my PhD in Regis Giet's Lab "Cytoskeleton and Cell Proliferation" at the institute of Genetics and Development of Rennes (IGDR), France. I have used Drosophila tissues, embryos, a combination of genetics, live imaging and in vitro biochemical assays to investigate how interference with microtubules (and the Microtubule Associated Proteins) affects spindle assembly, spindle orientation, chromosomes segregation and ultimately cell proliferation. During my PhD, I worked on Drosophila larval brain, and particularly on the neuroblast (neural stem cell). I have identified an Aurora A-dependant mechanism that promotes efficient and timed CyclinB degradation for anaphase onset, independently of the Spindle Assembly Checkpoint.
After my PhD, I have joined the Gruneberg’s Lab. I use a combination of molecular and cellular biology as well as live cell imaging to investigate the role of protein kinases and phosphatases in chromosomes segregation and cell division.