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Publications

2017

Gruneberg, U. and Barr, F. (2017) Organelle inheritance - what players have skin in the game? Science 355, 459-460.

2014

Espert, A., Uluocak, P., Nunes Bastos, R., Mangat, D., Graab, P. and Gruneberg, U. (2014) PP2A-B56 promotes spindle assembly checkpoint silencing by dephosphorylating Knl1. J. Cell Biol. 206, 833-842.

2013

Cundell, M.J., Bastos, R.N., Zhang, T., Holder, J., Gruneberg, U., Novak, B. and Barr, F.A. (2013) The BEG (PP2A-B55/ENSA/Greatwall) Pathway Ensures Cytokinesis follows Chromosome Separation. Mol. Cell 52, 393-405.

Nunes Bastos, R., Gandhi, S.R., Baron, R.D., Gruneberg, U., Nigg, E.A. and Barr, F.A. (2013) Aurora B suppresses microtubule dynamics and limits central spindle size by locally activating KIF4A. J Cell Biol. 202, 605-621.

Hammond, D., Zeng, K., Espert, A., Bastos, R.N., Baron, R.D., Gruneberg, U*. and Barr, F.A*. (2013) Melanoma-associated mutations in protein phosphatase 6 cause chromosome instability and DNA damage owing to dysregulated Aurora A . J Cell Sci. 126, 3429-3440. *joint corresponding authors

2012

Dunsch, A.K., Hammond, D., Lloyd, J., Schermelleh, L., Gruneberg, U, Barr F.A. (2012) Dynein light chain 1 and a spindle-associated adaptor promote dynein asymmetry and spindle orientation. J Cell Biol. 198, 1039-54.

2011

Barr, F.A., Elliot, P. and Gruneberg, U. (2011) Protein phosphatases and the regulation of mitosis. J Cell Sci. 124, 2323-2334.

Dunsch, A.K., Linnane, E., Barr, F.A. and Gruneberg, U. (2011) The astrin-kinastrin/SKAP complex localizes to microtubule plus-ends and controls chromosome alignment. J Cell Biol. 192, 959-968. 

2010

Zeng, K., Nunes-Bastos, R., Barr, F.A*. and Gruneberg, U*. (2010) Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A in complex with TPX2. J Cell Biol. 191, 1315-1332. *joint corresponding authors

2007

Barr, F.A. and Gruneberg, U. (2007) Cytokinesis: Placing and making the final cut. Cell 131, 847-855.

Thein, K.H., Kleylein-Sohn, J., Nigg, E.A. and Gruneberg, U. (2007) Astrin is required for the maintenance of sister chromatid cohesion and centrosome integrity. J Cell Biol. 178, 345-354.  

Neef, R., Gruneberg, U., Kopajtich, R., Körner, R., Nigg, E.A. Sillje, H. and Barr, F.A. (2007) Choice of Plk1 docking partners during mitosis is controlled by the activation state of Cdk1. Nat Cell Biol. 9, 436-444. 

2006

Klein, U.R., Nigg, E.A. and Gruneberg, U. (2006) Centromere targeting of the chromosomal passenger complex requires a ternary sub-complex of Borealin, Survivin and the very N-terminal domain of INCENP. Mol.Biol.Cell. 17, 2547-2558.

Gruneberg, U., Neef, R., Li, X., Chan, E.H.Y., Chalmalasetty, R.B., Nigg, E.A. and Barr, F.A. (2006) KIF14 and citron kinase act together to promote efficient cytokinesis. J Cell Biol. 172, 363-372. 

2005

Neef, R., Gruneberg, U., Barr, F.A. (2005) Assay and functional properties of Rabkinesin-6/Rab6-KIFL/MKlp2 in cytokinesis. Methods Enzymol. 403, 618-628.

2004

Mishima, M., Pavicic, V., Gruneberg, U., Nigg, E.A. and Glotzer, M. (2004) Cell cycle regulation of central spindle assembly. Nature 430, 908-913.

Gruneberg, U., Neef, R., Honda, R., Nigg, E.A. and Barr, F.A. (2004). Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2. J Cell Biol. 166, 167-172. 

2003

Gruneberg, U. and Nigg, E.A. (2003) Regulation of cell division: stop the SIN! Trends Cell Biol. 13,159-162. 

2002

Gruneberg, U., Glotzer, M., Gartner, A. and Nigg, E.A. (2002). The CeCDC-14 phosphatase is required for cytokinesis in the Caenorhabditis elegans embryo. J Cell Biol. 158, 901-914. 

2000

Gruneberg, U., Campbell, K., Simpson, C., Grindlay, J. and Schiebel, E. (2000). Nud1p links astral microtubule organisation and control of the exit from mitosis. EMBO J. 19, 6475-6488. 

van Ham, M., van Lith, M., Lillemeier, B., Tijn, E., Gruneberg, U., Rahman, D., Pastoors, L., van Meijgarden, K., Roucard, C., Trowsdale, J., Ottenhof, T., Pappin, D. and Neefjes, J. (2000). Modulation of the major histocompatibility complex class II-associated peptide repertoire by human histocompatibility leukocyte antigen (HLA)-DO. J. Exp. Med. 191, 1127-1135. 

1999

Pereira, G., Gruneberg, U.*, Knop, M. and Schiebel, E. (1999). Interaction of the yeast gamma-tubulin complex-binding protein Spc72p with Kar1p is essential for microtubule function during karyogamy. EMBO J. 18, 4180-4195. (*joint first author) 

Hitzel, C., Gruneberg, U., van Ham, S. M., Trowsdale, J. and Koch, N. (1999). Sodiumdodecyl sulfate-resistant HLA-DR “superdimer” bands are in some cases class II heterodimers bound to antibody. J. Immunol. 162, 4671-4676. 

1998

Rich, T., Gruneberg, U. and Trowsdale, J. (1998). Heat shock proteins, HLA-DR and rheumatoid arthritis. Nat Med. 4, 1210-1.

1997

Gruneberg, U., Rich, T., Roucard, C., van Ham, S. M., Charron, D., and Trowsdale, J. (1997). Two widely-used anti-DRa antibodies bind to an intracellular C-terminal epitope. Human Immunology 53, 34-38.

Ullrich, H. J., Doring, K., Gruneberg, U., Jahnig, F., Trowsdale, J., and van Ham, S. M. (1997). Interaction between HLA-DM and HLA-DR involves regions that undergo conformational changes at lysosomal pH. Proc. Natl. Acad. Sci. USA 94, 13163-13168.

van Ham, S. M., Tijn, E. P. M., Lillemeier, B. F., Gruneberg, U., van Meijgaarden, K. E., Pastoors, L., Verwoerd, D., Tulp, A., Canas, B., Rahman, D., Ottenhoff, T. H. M., Pappin, D. J. C., Trowsdale, J., and Neefjes, J. (1997). HLA-DO is a negative regulator of HLA-DM-mediated MHC class II peptide loading. Current Biology 7, 950-957.

1996

Beck, S., Belich, M., Gruneberg, U., Jackson, A., Kelly, A., Sanseau, P., Sanderson, F., Trowsdale, J., Van Ham, M. (1996).Organisation and functions of class II genes and molecules. DNA Seq. 7, 21-23.

van Ham, S. M., Gruneberg, U., Malcherek, G., Bröker, I., Melms, A., and Trowsdale, J. (1996). Human Histocompatibility Leukocyte Antigen (HLA)-DM edits peptides presented by HLA-DR according to their ligand binding motifs. J. Exp. Med. 184, 2019-2024. 

1995

Schild, H., Gruneberg, U., Pougialis, G., Wallny, H.-J., Keilholz, W., Stevanovic, S., and Rammensee, H.-G. (1995). Natural ligand motifs of H2-E molecules are allele-specific and illustrate homology to HLA-DR molecules. International Immunology 7, 1957-1965.